Ontology highlight
ABSTRACT:
SUBMITTER: Bartolowits M
PROVIDER: S-EPMC5464946 | biostudies-literature | 2016 Jan
REPOSITORIES: biostudies-literature
Chemical biology & drug design 20150831 1
While the fragment-based drug design approach continues to gain importance, gaps in the tools and methods available in the identification and accurate utilization of protein subpockets have limited the scope. The importance of these features of small molecule-protein recognition is highlighted with several examples. A generalized solution for the identification of subpockets and corresponding chemical fragments remains elusive, but there are numerous advancements in methods that can be used in c ...[more]