Ontology highlight
ABSTRACT:
SUBMITTER: Deckert V
PROVIDER: S-EPMC5465182 | biostudies-literature | 2017 Jun
REPOSITORIES: biostudies-literature
Scientific reports 20170608 1
Although plasma phospholipid transfer protein (PLTP) has been mainly studied in the context of atherosclerosis, it shares homology with proteins involved in innate immunity. Here, we produced active recombinant human PLTP (rhPLTP) in the milk of new lines of transgenic rabbits. We successfully used rhPLTP as an exogenous therapeutic protein to treat endotoxemia and sepsis. In mouse models with injections of purified lipopolysaccharides or with polymicrobial infection, we demonstrated that rhPLTP ...[more]