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Structural basis of the lipid transfer mechanism of phospholipid transfer protein (PLTP).

ABSTRACT: Human phospholipid transfer protein (PLTP) mediates the transfer of phospholipids among atheroprotective high-density lipoproteins (HDL) and atherogenic low-density lipoproteins (LDL) by an unknown mechanism. Delineating this mechanism would represent the first step towards understanding PLTP-mediated lipid transfers, which may be important for treating lipoprotein abnormalities and cardiovascular disease. Here, using various electron microscopy techniques, PLTP is revealed to have a banana-shaped structure similar to cholesteryl ester transfer protein (CETP). We provide evidence that PLTP penetrates into the HDL and LDL surfaces, respectively, and then forms a ternary complex with HDL and LDL. Insights into the interaction of PLTP with lipoproteins at the molecular level provide a basis to understand the PLTP-dependent lipid transfer mechanisms for dyslipidemia treatment.

SUBMITTER: Zhang M

PROVIDER: S-EPMC6114099 | biostudies-literature | 2018 Sep

REPOSITORIES: biostudies-literature

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Structural basis of the lipid transfer mechanism of phospholipid transfer protein (PLTP).

Zhang Meng M Zhai Xiaobo X Li Jinping J Albers John J JJ Vuletic Simona S Ren Gang G

Biochimica et biophysica acta. Molecular and cell biology of lipids 20180605 9

Human phospholipid transfer protein (PLTP) mediates the transfer of phospholipids among atheroprotective high-density lipoproteins (HDL) and atherogenic low-density lipoproteins (LDL) by an unknown mechanism. Delineating this mechanism would represent the first step towards understanding PLTP-mediated lipid transfers, which may be important for treating lipoprotein abnormalities and cardiovascular disease. Here, using various electron microscopy techniques, PLTP is revealed to have a banana-shap ...[more]

PMID: 29883800

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