Ontology highlight
ABSTRACT:
SUBMITTER: Fernandez-de-Cossio-Diaz J
PROVIDER: S-EPMC5465218 | biostudies-literature | 2017 Jun
REPOSITORIES: biostudies-literature
Fernandez-de-Cossio-Diaz Jorge J De Martino Andrea A Mulet Roberto R
Scientific reports 20170608 1
We introduce an in silico model for the initial spread of an aberrant phenotype with Warburg-like overflow metabolism within a healthy homeostatic tissue in contact with a nutrient reservoir (the blood), aimed at characterizing the role of the microenvironment for aberrant growth. Accounting for cellular metabolic activity, competition for nutrients, spatial diffusion and their feedbacks on aberrant replication and death rates, we obtain a phase portrait where distinct asymptotic whole-tissue st ...[more]