Ontology highlight
ABSTRACT:
SUBMITTER: Wedekind JE
PROVIDER: S-EPMC5465474 | biostudies-literature | 2017 Jun
REPOSITORIES: biostudies-literature
Wedekind Joseph E JE Dutta Debapratim D Belashov Ivan A IA Jenkins Jermaine L JL
The Journal of biological chemistry 20170428 23
Divalent ions fulfill essential cellular roles and are required for virulence by certain bacteria. Free intracellular Mg<sup>2+</sup> can approach 5 mm, but at this level Mn<sup>2+</sup>, Ni<sup>2+</sup>, or Co<sup>2+</sup> can be growth-inhibitory, and magnesium fluoride is toxic. To maintain ion homeostasis, many bacteria have evolved ion sensors embedded in the 5'-leader sequences of mRNAs encoding ion uptake or efflux channels. Here, we review current insights into these "metalloriboswitches ...[more]