Illuminating cytochrome P450 binding: Ru(ii)-caged inhibitors of CYP17A1.
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ABSTRACT:
SUBMITTER: Li A
PROVIDER: S-EPMC5468790 | biostudies-literature | 2017 Mar
REPOSITORIES: biostudies-literature
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Illuminating cytochrome P450 binding: Ru(ii)-caged inhibitors of CYP17A1.
Li Ao A Yadav Rahul R White Jessica K JK Herroon Mackenzie K MK Callahan Brian P BP Podgorski Izabela I Turro Claudia C Scott Emily E EE Kodanko Jeremy J JJ
Chemical communications (Cambridge, England) 20170301 26
New Ru(ii)-caged abiraterone complexes were synthesized that exhibit strong absorption in the visible region and release the steroidal CYP17A1 inhibitor abiraterone upon exposure to low energy visible light in buffer and prostate cancer cells. Photoinduced release results in abiraterone binding to its CYP17A1 target in an inhibitory mode. ...[more]
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