Ontology highlight
ABSTRACT:
SUBMITTER: Kaltgrad E
PROVIDER: S-EPMC5469293 | biostudies-literature | 2008 Apr
REPOSITORIES: biostudies-literature
Kaltgrad Eiton E O'Reilly Mary K MK Liao Liang L Han Shoufa S Paulson James C JC Finn M G MG
Journal of the American Chemical Society 20080315 14
Glycans arrayed on the exterior of virus particles were used as substrates for glycosyltransferase reactions to build di- and trisaccharides from the virus surface. The resulting particles exhibited tight and specific associations with cognate receptors on beads and cells, in one example defeating in cis cell-surface interactions in a manner characteristic of polyvalent binding. Combined with the ability of viruses to provide structurally well-defined attachment points, the methodology provides ...[more]