Ontology highlight
ABSTRACT:
SUBMITTER: McKay CS
PROVIDER: S-EPMC6939865 | biostudies-literature | 2016 Oct
REPOSITORIES: biostudies-literature
Angewandte Chemie (International ed. in English) 20160530 41
Unusually fast rates of nucleophilic catalysis of hydrazone ligation were observed when polyvalent anthranilic acid catalysts operating on polyvalent aldehyde substrates were used with PAMAM dendrimers as the common platform. When presented in this way, the catalyst has a strong accelerating effect at concentrations 40-400 times lower than those required for similar monovalent catalysts and displays unique kinetic parameters. We attribute these properties to polyvalent engagement between the den ...[more]