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Antidiabetic Drugs in Alzheimer's Disease: Mechanisms of Action and Future Perspectives.

ABSTRACT: Diabetes mellitus (DM) and Alzheimer's disease (AD) are two highly prevalent conditions in the elderly population and major public health burden. In the past decades, a pathophysiological link between DM and AD has emerged and central nervous system insulin resistance might play a significant role as a common mechanism; however, other factors such as inflammation and oxidative stress seem to contribute to the shared pathophysiological link. Both preclinical and clinical studies have evaluated the possible neuroprotective mechanisms of different classes of antidiabetic medications in AD, with some promising results. Here, we review the evidence on the mechanisms of action of antidiabetic drugs and their potential use in AD.

SUBMITTER: Femminella GD

PROVIDER: S-EPMC5471577 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature

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Antidiabetic Drugs in Alzheimer's Disease: Mechanisms of Action and Future Perspectives.

Femminella Grazia Daniela GD Bencivenga Leonardo L Petraglia Laura L Visaggi Lucia L Gioia Lucia L Grieco Fabrizio Vincenzo FV de Lucia Claudio C Komici Klara K Corbi Graziamaria G Edison Paul P Rengo Giuseppe G Ferrara Nicola N

Journal of diabetes research 20170601

Diabetes mellitus (DM) and Alzheimer's disease (AD) are two highly prevalent conditions in the elderly population and major public health burden. In the past decades, a pathophysiological link between DM and AD has emerged and central nervous system insulin resistance might play a significant role as a common mechanism; however, other factors such as inflammation and oxidative stress seem to contribute to the shared pathophysiological link. Both preclinical and clinical studies have evaluated th ...[more]

PMID: 28656154

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