Ontology highlight
ABSTRACT:
SUBMITTER: Teixeira JP
PROVIDER: S-EPMC6930470 | biostudies-literature | 2019 Dec
REPOSITORIES: biostudies-literature
Teixeira Jéssika P JP de Castro Alexandre A AA Soares Flávia V FV da Cunha Elaine F F EFF Ramalho Teodorico C TC
Molecules (Basel, Switzerland) 20191203 23
Alzheimer's disease (AD) is a neurodegenerative disease that is usually accompanied by aging, increasingly being the most common cause of dementia in the elderly. This disorder is characterized by the accumulation of beta amyloid plaques (Aβ) resulting from impaired amyloid precursor protein (APP) metabolism, together with the formation of neurofibrillary tangles and tau protein hyperphosphorylation. The exacerbated production of reactive oxygen species (ROS) triggers the process called oxidativ ...[more]