Facile Coating Strategy to Functionalize Inorganic Nanoparticles for Biosensing.
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ABSTRACT:
SUBMITTER: Park YI
PROVIDER: S-EPMC5474933 | biostudies-literature | 2017 Jan
REPOSITORIES: biostudies-literature
Publications
Facile Coating Strategy to Functionalize Inorganic Nanoparticles for Biosensing.
Park Yong Il YI Kim Eunha E Huang Chen-Han CH Park Ki Soo KS Castro Cesar M CM Lee Hakho H Weissleder Ralph R
Bioconjugate chemistry 20161107 1
The use of inorganic nanoparticles (NPs) for biosensing requires that they exhibit high colloidal stability under various physiological conditions. Here, we report on a general approach to render hydrophobic NPs into hydrophilic ones that are ready for bioconjugation. The method uses peglyated polymers conjugated with multiple dopamines, which results in multidentate coordination. As proof-of-concept, we applied the coating to stabilize ferrite and lanthanide NPs synthesized by thermal decomposi ...[more]
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