Macrophages Facilitate Electrical Conduction in the Heart.
Ontology highlight
ABSTRACT:
SUBMITTER: Hulsmans M
PROVIDER: S-EPMC5474950 | biostudies-literature | 2017 Apr
REPOSITORIES: biostudies-literature
Publications
Macrophages Facilitate Electrical Conduction in the Heart.
Hulsmans Maarten M Clauss Sebastian S Xiao Ling L Aguirre Aaron D AD King Kevin R KR Hanley Alan A Hucker William J WJ Wülfers Eike M EM Seemann Gunnar G Courties Gabriel G Iwamoto Yoshiko Y Sun Yuan Y Savol Andrej J AJ Sager Hendrik B HB Lavine Kory J KJ Fishbein Gregory A GA Capen Diane E DE Da Silva Nicolas N Miquerol Lucile L Wakimoto Hiroko H Seidman Christine E CE Seidman Jonathan G JG Sadreyev Ruslan I RI Naxerova Kamila K Mitchell Richard N RN Brown Dennis D Libby Peter P Weissleder Ralph R Swirski Filip K FK Kohl Peter P Vinegoni Claudio C Milan David J DJ Ellinor Patrick T PT Nahrendorf Matthias M
Cell 20170401 3
Organ-specific functions of tissue-resident macrophages in the steady-state heart are unknown. Here, we show that cardiac macrophages facilitate electrical conduction through the distal atrioventricular node, where conducting cells densely intersperse with elongated macrophages expressing connexin 43. When coupled to spontaneously beating cardiomyocytes via connexin-43-containing gap junctions, cardiac macrophages have a negative resting membrane potential and depolarize in synchrony with cardio ...[more]
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