Ontology highlight
ABSTRACT:
SUBMITTER: Chung S
PROVIDER: S-EPMC5477115 | biostudies-literature | 2017 Jun
REPOSITORIES: biostudies-literature
Chung Stacey S Jin Yanli Y Han Bingchen B Qu Ying Y Gao Bowen B Giuliano Armando E AE Cui Xiaojiang X
Cell communication and signaling : CCS 20170619 1
<h4>Background</h4>The pathogenesis of human basal-like breast cancer (BLBC) is not well understood and patients with BLBC have a poor prognosis. Expression of the epidermal growth factor receptor (EGFR) and nuclear factor-κB (NF-κB) is well-known to be upregulated in BLBC. The forkhead box C1 (FOXC1) transcription factor, an important prognostic biomarker specific for BLBC, has been shown to be induced by EGF and is critical for EGF effects in breast cancer cells. How FOXC1 is transcriptionally ...[more]