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Exploiting recognition-mediated assembly and reactivity in [2]rotaxane formation.

ABSTRACT: A small molecular reaction network exploits recognition-mediated reactive processes in order to drive the assembly and formation of both a self-replicating linear template (thread) and a [2]rotaxane, in which the linear template is encircled by a diamide macrocycle. Complementary recognition sites, placed at strategic positions on the reactive building blocks, drive these assembly and replication processes. Template-instructed experiments show that the thread is capable of efficient self-replication and that no cross-catalytic relationships exist between the thread and the [2]rotaxane. The rate of [2]rotaxane formation is insensitive to the addition of a preformed template, however, [2]rotaxane formation does show enhanced diastereoselectivity, most likely originating from its recognition-mediated formation through a ternary reactive complex.

SUBMITTER: Vidonne A

PROVIDER: S-EPMC5477148 | biostudies-literature | 2016 Apr

REPOSITORIES: biostudies-literature

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Exploiting recognition-mediated assembly and reactivity in [2]rotaxane formation.

Vidonne Annick A Kosikova Tamara T Philp Douglas D

Chemical science 20160115 4

A small molecular reaction network exploits recognition-mediated reactive processes in order to drive the assembly and formation of both a self-replicating linear template (thread) and a [2]rotaxane, in which the linear template is encircled by a diamide macrocycle. Complementary recognition sites, placed at strategic positions on the reactive building blocks, drive these assembly and replication processes. Template-instructed experiments show that the thread is capable of efficient self-replica ...[more]

PMID: 28660031

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