Ontology highlight
ABSTRACT:
SUBMITTER: Zhang X
PROVIDER: S-EPMC5477577 | biostudies-literature | 2017 Apr
REPOSITORIES: biostudies-literature
Zhang Xudong X Wang Chuandong C Zhao Jingyu J Xu Jiajia J Geng Yiyun Y Dai Liming L Huang Yan Y Fu Sai-Chuen SC Dai Kerong K Zhang Xiaoling X
Cell death & disease 20170406 4
Osteoarthritis (OA), characterized by insufficient extracellular matrix synthesis and cartilage degeneration, is known as an incurable disease because its pathogenesis is poorly elucidated. Thus far, limited information is available regarding the pathophysiological role of microRNAs (miRNAs) in OA. In this study, we investigated the specific function of miR-146a in OA pathophysiology using mouse OA models. We found that the articular cartilage degeneration of miR-146a knockout (KO) mice was alle ...[more]