Ontology highlight
ABSTRACT:
SUBMITTER: Kvon EZ
PROVIDER: S-EPMC5484524 | biostudies-literature | 2016 Oct
REPOSITORIES: biostudies-literature
Cell 20161001 3
The evolution of body shape is thought to be tightly coupled to changes in regulatory sequences, but specific molecular events associated with major morphological transitions in vertebrates have remained elusive. We identified snake-specific sequence changes within an otherwise highly conserved long-range limb enhancer of Sonic hedgehog (Shh). Transgenic mouse reporter assays revealed that the in vivo activity pattern of the enhancer is conserved across a wide range of vertebrates, including fis ...[more]