Ontology highlight
ABSTRACT:
SUBMITTER: Werth M
PROVIDER: S-EPMC5484618 | biostudies-literature | 2017 Jun
REPOSITORIES: biostudies-literature
eLife 20170603
Although most nephron segments contain one type of epithelial cell, the collecting ducts consists of at least two: intercalated (IC) and principal (PC) cells, which regulate acid-base and salt-water homeostasis, respectively. In adult kidneys, these cells are organized in rosettes suggesting functional interactions. Genetic studies in mouse revealed that transcription factor <i>Tfcp2l1</i> coordinates IC and PC development. <i>Tfcp2l1</i> induces the expression of IC specific genes, including sp ...[more]