Ontology highlight
ABSTRACT:
SUBMITTER: Song X
PROVIDER: S-EPMC5485633 | biostudies-literature | 2017
REPOSITORIES: biostudies-literature
Song Xiaoling X Wang Zheng Z Liang Haibin H Zhang Wenjie W Ye Yuanyuan Y Li HuaiFeng H Hu Yunping Y Zhang Yijian Y Weng Hao H Lu Jianhua J Wang Xuefeng X Li Maolan M Liu Yingbin Y Gu Jun J
International journal of biological sciences 20170601 6
Gallbladder cancer (GBC), highly aggressive form of cancer with an extremely poor prognosis, is the most common malignancy of the biliary tract. In this study, we investigated the effects of dioscin (DSN) on human GBC and the potential mechanisms underlying these effects. The results showed that DSN significantly inhibited GBC cell proliferation and migration. Moreover, DSN induced GBC cell apoptosis via mitochondrial dependent apoptotic signalling. Reactive oxygen species (ROS) and glutathione ...[more]