Ontology highlight
ABSTRACT:
SUBMITTER: Passardi A
PROVIDER: S-EPMC5486145 | biostudies-literature | 2017 Jun
REPOSITORIES: biostudies-literature
Passardi Alessandro A Canale Matteo M Valgiusti Martina M Ulivi Paola P
International journal of molecular sciences 20170621 6
Anti-tumor immunity is a new line of research for the treatment of patients with solid tumors. In this field, negative regulators of the immune system called immune checkpoints play a key role in limiting antitumor immunologic responses. For this reason, immune checkpoint-inhibiting agents, such as those directed against cytotoxic T-lymphocyte antigen 4 (CTLA-4) and programmed death-1 receptor (PD1) and its ligand PD-L1, have been developed as antitumor drugs, producing interesting results in pr ...[more]