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Phenotypic and Molecular Evaluation of Echinocandin Susceptibility of Candida glabrata, Candida bracarensis, and Candida nivariensis Strains Isolated during 30 Years in Argentina.

ABSTRACT: The echinocandin susceptibilities of 122 Candida glabrata complex strains (including 5 Candida nivariensis and 3 Candida bracarensis strains) were evaluated by microdilution and compared with the results from a molecular tool able to detect FKS mutations. No echinocandin resistance was detected. The PCR results coincide with the MIC data in 99.25% of the cases (1 C. glabrata strain was misidentified as resistant) but were 20 h faster. C. nivariensis FKS genes were sequenced and showed differences with C. glabrataFKS genes.

SUBMITTER: Morales-Lopez S 

PROVIDER: S-EPMC5487631 | biostudies-literature | 2017 Jul

REPOSITORIES: biostudies-literature

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Phenotypic and Molecular Evaluation of Echinocandin Susceptibility of Candida glabrata, Candida bracarensis, and Candida nivariensis Strains Isolated during 30 Years in Argentina.

Morales-López Soraya S   Dudiuk Catiana C   Vivot Walter W   Szusz Wanda W   Córdoba Susana B SB   Garcia-Effron Guillermo G  

Antimicrobial agents and chemotherapy 20170627 7

The echinocandin susceptibilities of 122 <i>Candida glabrata</i> complex strains (including 5 <i>Candida nivariensis</i> and 3 <i>Candida bracarensis</i> strains) were evaluated by microdilution and compared with the results from a molecular tool able to detect FKS mutations. No echinocandin resistance was detected. The PCR results coincide with the MIC data in 99.25% of the cases (1 <i>C. glabrata</i> strain was misidentified as resistant) but were 20 h faster. <i>C. nivariensis FKS</i> genes w  ...[more]

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