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Adaptive and freeze-tolerant heteronetwork organohydrogels with enhanced mechanical stability over a wide temperature range.

ABSTRACT: Many biological organisms with exceptional freezing tolerance can resist the damages to cells from extra-/intracellular ice crystals and thus maintain their mechanical stability at subzero temperatures. Inspired by the freezing tolerance mechanisms found in nature, here we report a strategy of combining hydrophilic/oleophilic heteronetworks to produce self-adaptive, freeze-tolerant and mechanically stable organohydrogels. The organohydrogels can simultaneously use water and oil as a dispersion medium, and quickly switch between hydrogel- and organogel-like behaviours in response to the nature of the surrounding phase. Accordingly, their surfaces display unusual adaptive dual superlyophobic in oil/water system (that is, they are superhydrophobic under oil and superoleophobic under water). Moreover, the organogel component can inhibit the ice crystallization of the hydrogel component, thus enhancing the mechanical stability of organohydrogel over a wide temperature range (-78 to 80?°C). The organohydrogels may have promising applications in complex and harsh environments.

SUBMITTER: Gao H

PROVIDER: S-EPMC5489716 | biostudies-literature | 2017 Jun

REPOSITORIES: biostudies-literature

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Adaptive and freeze-tolerant heteronetwork organohydrogels with enhanced mechanical stability over a wide temperature range.

Gao Hainan H Zhao Ziguang Z Cai Yudong Y Zhou Jiajia J Hua Wenda W Chen Lie L Wang Li L Zhang Jianqi J Han Dong D Liu Mingjie M Jiang Lei L

Nature communications 20170622

Many biological organisms with exceptional freezing tolerance can resist the damages to cells from extra-/intracellular ice crystals and thus maintain their mechanical stability at subzero temperatures. Inspired by the freezing tolerance mechanisms found in nature, here we report a strategy of combining hydrophilic/oleophilic heteronetworks to produce self-adaptive, freeze-tolerant and mechanically stable organohydrogels. The organohydrogels can simultaneously use water and oil as a dispersion m ...[more]

PMID: 28639615

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Project description:BACKGROUND:Adaptive mechanical ventilation automatically adjusts respiratory rate (RR) and tidal volume (VT) to deliver the clinically desired minute ventilation, selecting RR and VT based on Otis' equation on least work of breathing. However, the resulting VT may be relatively high, especially in patients with more compliant lungs. Therefore, a new mode of adaptive ventilation (adaptive ventilation mode 2, AVM2) was developed which automatically minimizes inspiratory power with the aim of ensuring lung-protective combinations of VT and RR. The aim of this study was to investigate whether AVM2 reduces VT, mechanical power, and driving pressure (?Pstat) and provides similar gas exchange when compared to adaptive mechanical ventilation based on Otis' equation. METHODS:A prospective randomized cross-over study was performed in 20 critically ill patients on controlled mechanical ventilation, including 10 patients with acute respiratory distress syndrome (ARDS). Each patient underwent 1 h of mechanical ventilation with AVM2 and 1 h of adaptive mechanical ventilation according to Otis' equation (adaptive ventilation mode, AVM). At the end of each phase, we collected data on VT, mechanical power, ?P, PaO2/FiO2 ratio, PaCO2, pH, and hemodynamics. RESULTS:Comparing adaptive mechanical ventilation with AVM2 to the approach based on Otis' equation (AVM), we found a significant reduction in VT both in the whole study population (7.2?±?0.9 vs. 8.2?±?0.6?ml/kg, p?<? 0.0001) and in the subgroup of patients with ARDS (6.6?±?0.8?ml/kg with AVM2 vs. 7.9?±?0.5?ml/kg with AVM, p?<? 0.0001). Similar reductions were observed for ?Pstat (whole study population: 11.5?±?1.6 cmH2O with AVM2 vs. 12.6?±?2.5 cmH2O with AVM, p?<? 0.0001; patients with ARDS: 11.8?±?1.7 cmH2O with AVM2 and 13.3?±?2.7 cmH2O with AVM, p?=?0.0044) and total mechanical power (16.8?±?3.9?J/min with AVM2 vs. 18.6?±?4.6?J/min with AVM, p?=?0.0024; ARDS: 15.6?±?3.2?J/min with AVM2 vs. 17.5?±?4.1?J/min with AVM, p?=?0.0023). There was a small decrease in PaO2/FiO2 (270?±?98 vs. 291?±?102?mmHg with AVM, p?=?0.03; ARDS: 194?±?55 vs. 218?±?61 with AVM, p?=?0.008) and no differences in PaCO2, pH, and hemodynamics. CONCLUSIONS:Adaptive mechanical ventilation with automated minimization of inspiratory power may lead to more lung-protective ventilator settings when compared with adaptive mechanical ventilation according to Otis' equation. TRIAL REGISTRATION:The study was registered at the German Clinical Trials Register ( DRKS00013540 ) on December 1, 2017, before including the first patient.

Dataset Information

Adaptive and freeze-tolerant heteronetwork organohydrogels with enhanced mechanical stability over a wide temperature range.

Publications

Adaptive and freeze-tolerant heteronetwork organohydrogels with enhanced mechanical stability over a wide temperature range.

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