Ontology highlight
ABSTRACT:
SUBMITTER: Vijayaraghavan S
PROVIDER: S-EPMC5490269 | biostudies-literature | 2017 Jun
REPOSITORIES: biostudies-literature
Vijayaraghavan Smruthi S Karakas Cansu C Doostan Iman I Chen Xian X Bui Tuyen T Yi Min M Raghavendra Akshara S AS Zhao Yang Y Bashour Sami I SI Ibrahim Nuhad K NK Karuturi Meghan M Wang Jing J Winkler Jeffrey D JD Amaravadi Ravi K RK Hunt Kelly K KK Tripathy Debu D Keyomarsi Khandan K
Nature communications 20170627
Deregulation of the cell cycle machinery is a hallmark of cancer. While CDK4/6 inhibitors are FDA approved (palbociclib) for treating advanced estrogen receptor-positive breast cancer, two major clinical challenges remain: (i) adverse events leading to therapy discontinuation and (ii) lack of reliable biomarkers. Here we report that breast cancer cells activate autophagy in response to palbociclib, and that the combination of autophagy and CDK4/6 inhibitors induces irreversible growth inhibition ...[more]