Ontology highlight
ABSTRACT:
SUBMITTER: MacDonald KP
PROVIDER: S-EPMC5490762 | biostudies-literature | 2017 Jun
REPOSITORIES: biostudies-literature
MacDonald Kelli Pa KP Blazar Bruce R BR Hill Geoffrey R GR
The Journal of clinical investigation 20170630 7
Substantial preclinical and clinical research into chronic graft-versus-host disease (cGVHD) has come to fruition in the last five years, generating a clear understanding of a complex cytokine-driven cellular network. cGVHD is mediated by naive T cells differentiating within IL-17-secreting T cell and follicular Th cell paradigms to generate IL-21 and IL-17A, which drive pathogenic germinal center (GC) B cell reactions and monocyte-macrophage differentiation, respectively. cGVHD pathogenesis inc ...[more]