Ontology highlight
ABSTRACT:
SUBMITTER: DeSelm CJ
PROVIDER: S-EPMC5491361 | biostudies-literature | 2017 Jul
REPOSITORIES: biostudies-literature
Journal of surgical oncology 20170327 1
Chimeric antigen receptor (CAR) T-cell therapy utilizes genetic engineering to redirect a patient's own T cells to target cancer cells. The remarkable results in hematological malignancies prompted investigating this approach in solid tumors such as pancreatic cancer. The complex tumor microenvironment, stromal hindrance in limiting immune response, and expression of checkpoint blockade on T cells pose hurdles. Herein, we summarize the opportunities, challenges, and state of knowledge in targeti ...[more]