Ontology highlight
ABSTRACT:
SUBMITTER: Facchinello N
PROVIDER: S-EPMC5491532 | biostudies-literature | 2017 Jun
REPOSITORIES: biostudies-literature
Facchinello N N Skobo T T Meneghetti G G Colletti E E Dinarello A A Tiso N N Costa R R Gioacchini G G Carnevali O O Argenton F F Colombo L L Dalla Valle L L
Scientific reports 20170629 1
Glucocorticoids (GCs) play important roles in developmental and physiological processes through the transcriptional activity of their cognate receptor (Gr). Using CRISPR/Cas9 technology, we established a zebrafish null Gr mutant line and compared its phenotypes with wild type and a zebrafish line with partially silenced gr (gr <sup>s357/s357</sup> ). Homozygous gr <sup>-/-</sup> larvae are morphologically inconspicuous and, in contrast to GR <sup>-/-</sup> knockout mice, viable through adulthood ...[more]