PPAR? Promotes Running Endurance by Preserving Glucose.
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ABSTRACT:
SUBMITTER: Fan W
PROVIDER: S-EPMC5492977 | biostudies-literature | 2017 May
REPOSITORIES: biostudies-literature
Publications
PPARδ Promotes Running Endurance by Preserving Glucose.
Fan Weiwei W Waizenegger Wanda W Lin Chun Shi CS Sorrentino Vincenzo V He Ming-Xiao MX Wall Christopher E CE Li Hao H Liddle Christopher C Yu Ruth T RT Atkins Annette R AR Auwerx Johan J Downes Michael M Evans Ronald M RM
Cell metabolism 20170501 5
Management of energy stores is critical during endurance exercise; a shift in substrate utilization from glucose toward fat is a hallmark of trained muscle. Here we show that this key metabolic adaptation is both dependent on muscle PPARδ and stimulated by PPARδ ligand. Furthermore, we find that muscle PPARδ expression positively correlates with endurance performance in BXD mouse reference populations. In addition to stimulating fatty acid metabolism in sedentary mice, PPARδ activation potently ...[more]
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