Ontology highlight
ABSTRACT:
SUBMITTER: Caldwell JM
PROVIDER: S-EPMC5496811 | biostudies-literature | 2017 Sep
REPOSITORIES: biostudies-literature
Caldwell J M JM Collins M H MH Kemme K A KA Sherrill J D JD Wen T T Rochman M M Stucke E M EM Amin L L Tai H H Putnam P E PE Jiménez-Dalmaroni M J MJ Wormald M R MR Porollo A A Abonia J P JP Rothenberg M E ME
Mucosal immunology 20170104 5
Cadherins (CDH) mediate diverse processes critical in inflammation, including cell adhesion, migration, and differentiation. Herein, we report that the uncharacterized cadherin 26 (CDH26) is highly expressed by epithelial cells in human allergic gastrointestinal tissue. In vitro, CDH26 promotes calcium-dependent cellular adhesion of cells lacking endogenous CDHs by a mechanism involving homotypic binding and interaction with catenin family members (alpha, beta, and p120), as assessed by biochemi ...[more]