Ontology highlight
ABSTRACT:
SUBMITTER: Hirano M
PROVIDER: S-EPMC2542480 | biostudies-literature | 2008 Sep
REPOSITORIES: biostudies-literature
Hirano Mariko M Hashimoto Shigeru S Yonemura Shigenobu S Sabe Hisataka H Aizawa Shinichi S
The Journal of cell biology 20080915 6
EPB41L5 belongs to the band 4.1 superfamily. We investigate here the involvement of EPB41L5 in epithelial-mesenchymal transition (EMT) during mouse gastrulation. EPB41L5 expression is induced during TGFbeta-stimulated EMT, whereas silencing of EPB41L5 by siRNA inhibits this transition. In EPB41L5 mutants, cell-cell adhesion is enhanced, and EMT is greatly impaired during gastrulation. Moreover, cell attachment, spreading, and mobility are greatly reduced by EPB41L5 deficiency. Gene transcription ...[more]