Ontology highlight
ABSTRACT:
SUBMITTER: Takii R
PROVIDER: S-EPMC5501597 | biostudies-literature | 2017
REPOSITORIES: biostudies-literature
Takii Ryosuke R Fujimoto Mitsuaki M Matsuura Yuki Y Wu Fangxu F Oshibe Namiko N Takaki Eiichi E Katiyar Arpit A Akashi Hiroshi H Makino Takashi T Kawata Masakado M Nakai Akira A
PloS one 20170707 7
Cells cope with temperature elevations, which cause protein misfolding, by expressing heat shock proteins (HSPs). This adaptive response is called the heat shock response (HSR), and it is regulated mainly by heat shock transcription factor (HSF). Among the four HSF family members in vertebrates, HSF1 is a master regulator of HSP expression during proteotoxic stress including heat shock in mammals, whereas HSF3 is required for the HSR in birds. To examine whether only one of the HSF family member ...[more]