Ontology highlight
ABSTRACT:
SUBMITTER: Heit A
PROVIDER: S-EPMC5502430 | biostudies-literature | 2017 Jul
REPOSITORIES: biostudies-literature
The Journal of experimental medicine 20170621 7
Germinal center T follicular helper cells (GCTfh) in lymphatic tissue are critical for B cell differentiation and protective antibody induction, but whether GCTfh establish clonal derivatives as circulating memory T cells is less understood. Here, we used markers expressed on GCTfh, CXCR5, PD1, and ICOS, to identify potential circulating CXCR5<sup>+</sup>CD4<sup>+</sup> Tfh-like cells (cTfh) in humans, and investigated their functional phenotypes, diversity, and ontogeny in paired donor blood an ...[more]