Ontology highlight
ABSTRACT:
SUBMITTER: Rana S
PROVIDER: S-EPMC5506780 | biostudies-literature | 2015 Jan
REPOSITORIES: biostudies-literature
Rana Subinoy S Le Ngoc D B ND Mout Rubul R Saha Krishnendu K Tonga Gulen Yesilbag GY Bain Robert E S RE Miranda Oscar R OR Rotello Caren M CM Rotello Vincent M VM
Nature nanotechnology 20141215 1
Screening methods that use traditional genomic, transcriptional, proteomic and metabonomic signatures to characterize drug mechanisms are known. However, they are time consuming and require specialized equipment. Here, we present a high-throughput multichannel sensor platform that can profile the mechanisms of various chemotherapeutic drugs in minutes. The sensor consists of a gold nanoparticle complexed with three different fluorescent proteins that can sense drug-induced physicochemical change ...[more]