Ontology highlight
ABSTRACT:
SUBMITTER: Chen A
PROVIDER: S-EPMC5507973 | biostudies-literature | 2017 Jul
REPOSITORIES: biostudies-literature
Chen Aiping A Zhang Yonghui Y Meng Gang G Jiang Dengxu D Zhang Hailin H Zheng Meihong M Xia Mao M Jiang Aiqin A Wu Junhua J Beltinger Christian C Wei Jiwu J
Scientific reports 20170712 1
There is an urgent need for novel effective treatment for hepatocellular carcinoma (HCC). Oncolytic viruses (OVs) not only directly lyse malignant cells, but also induce potent antitumour immune responses. The potency and precise mechanisms of antitumour immune activation by attenuated measles virus remain unclear. In this study, we investigated the potency of the measles virus vaccine strain Edmonston (MV-Edm) in improving adoptive CD8<sup>+</sup>NKG2D<sup>+</sup> cells for HCC treatment. We sh ...[more]