Ontology highlight
ABSTRACT:
SUBMITTER: Franzini RM
PROVIDER: S-EPMC5508869 | biostudies-literature | 2008 Jul
REPOSITORIES: biostudies-literature
Organic letters 20080613 14
A nucleic acid detection scheme that employs DNA-mediated delivery of an organomercury activator to unmask a fluorophore is described. The approach relies on adjacent hybridization of two oligonucleotide conjugates containing organomercury and caged rhodamine functionalities. Postsynthetic conjugation of amino-modified DNAs enabled efficient preparation of these probes. Complementary DNA templates yielded fluorescence signals arising from metal-assisted rhodamine uncaging. ...[more]