Ontology highlight
ABSTRACT:
SUBMITTER: Cheret A
PROVIDER: S-EPMC5510829 | biostudies-literature | 2017
REPOSITORIES: biostudies-literature
Chéret Antoine A Durier Christine C Mélard Adeline A Ploquin Mickaël M Heitzmann Julia J Lécuroux Camille C Avettand-Fenoël Véronique V David Ludivine L Pialoux Gilles G Chennebault Jean-Marie JM Müller-Trutwin Michaela M Goujard Cécile C Rouzioux Christine C Meyer Laurence L
PloS one 20170714 7
<h4>Background</h4>HIV-infected cells in semen facilitate viral transmission. We studied the establishment of HIV reservoirs in semen and blood during PHI, along with systemic immune activation and the impact of early cART.<h4>Methods</h4>Patients in the ANRS-147-OPTIPRIM trial received two years of early cART. Nineteen patients of the trial were analyzed, out of which 8 had acute PHI (WB ≤1 Ab). We quantified total cell-associated (ca) HIV-DNA in blood and semen and HIV-RNA in blood and semen p ...[more]