Ontology highlight
ABSTRACT:
SUBMITTER: Narva E
PROVIDER: S-EPMC5511101 | biostudies-literature | 2017 Jul
REPOSITORIES: biostudies-literature
Närvä Elisa E Stubb Aki A Guzmán Camilo C Blomqvist Matias M Balboa Diego D Lerche Martina M Saari Markku M Otonkoski Timo T Ivaska Johanna J
Stem cell reports 20170615 1
Cell-type-specific functions and identity are tightly regulated by interactions between the cell cytoskeleton and the extracellular matrix (ECM). Human pluripotent stem cells (hPSCs) have ultimate differentiation capacity and exceptionally low-strength ECM contact, yet the organization and function of adhesion sites and associated actin cytoskeleton remain poorly defined. We imaged hPSCs at the cell-ECM interface with total internal reflection fluorescence microscopy and discovered that adhesion ...[more]