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Ligand-Promoted meta-C-H Functionalization of Benzylamines.

ABSTRACT: Meta-C-H functionalization of benzylamines has been developed using a PdII /transient mediator strategy. Using 2-pyridone ligands and 2-carbomethoxynorbornene (NBE-CO2 Me) as the mediator, arylation, amination, and chlorination of benzylamines are realized. This protocol features a broad substrate scope and is compatible with heterocylic coupling partners. Moreover, the loading of the Pd can be lowered to 2.5?mol?% by using the optimal ligand.

SUBMITTER: Wang P

PROVIDER: S-EPMC5512280 | biostudies-literature | 2017 Apr

REPOSITORIES: biostudies-literature

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Ligand-Promoted meta-C-H Functionalization of Benzylamines.

Wang Peng P Farmer Marcus E ME Yu Jin-Quan JQ

Angewandte Chemie (International ed. in English) 20170330 18

Meta-C-H functionalization of benzylamines has been developed using a Pd<sup>II</sup> /transient mediator strategy. Using 2-pyridone ligands and 2-carbomethoxynorbornene (NBE-CO<sub>2</sub> Me) as the mediator, arylation, amination, and chlorination of benzylamines are realized. This protocol features a broad substrate scope and is compatible with heterocylic coupling partners. Moreover, the loading of the Pd can be lowered to 2.5 mol % by using the optimal ligand. ...[more]

PMID: 28371173

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