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The basics of CAR T design and challenges in immunotherapy of solid tumors - Ovarian cancer as a model.

ABSTRACT: Chimeric antigen receptor T cells are T cells genetically engineered with CAR constructs which mainly contain scFV and TCR zeta chain. With promising development in blood cancers, CAR T trials are also applied in solid cancers. However, the treatment effect in solid cancers is lower than expected. This review summarizes difference of CAR T applications in solid and blood cancers. Future challenges of CAR T cell treatment in solid cancer are also discussed using ovarian cancer as an example.

SUBMITTER: Xu X

PROVIDER: S-EPMC5512759 | biostudies-literature | 2017 Jul

REPOSITORIES: biostudies-literature

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The basics of CAR T design and challenges in immunotherapy of solid tumors - Ovarian cancer as a model.

Xu Xuequn X Qiu Jin J Sun Yi Y

Human vaccines & immunotherapeutics 20170308 7

Chimeric antigen receptor T cells are T cells genetically engineered with CAR constructs which mainly contain scFV and TCR zeta chain. With promising development in blood cancers, CAR T trials are also applied in solid cancers. However, the treatment effect in solid cancers is lower than expected. This review summarizes difference of CAR T applications in solid and blood cancers. Future challenges of CAR T cell treatment in solid cancer are also discussed using ovarian cancer as an example. ...[more]

PMID: 28272967

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