Ontology highlight
ABSTRACT:
SUBMITTER: Burns LA
PROVIDER: S-EPMC7187427 | biostudies-literature | 2020 Apr
REPOSITORIES: biostudies-literature
Burns Lachrissa A LA Maroof Ash A Marshall Diane D Steel Kathryn J A KJA Lalnunhlimi Sylvine S Cole Suzanne S Catrina Anca A Kirkham Bruce B Taams Leonie S LS
European journal of immunology 20200116 4
The pro-inflammatory cytokine IL-17A has been implicated in the immunopathology of inflammatory arthritis. IL-17F bears 50% homology to IL-17A and has recently been suggested to play a role in inflammation. We investigated the induction and cytokine profile of IL-17F<sup>+</sup> CD4<sup>+</sup> T cells, and how IL-17F may contribute to inflammation. Upon culture of healthy donor CD4<sup>+</sup> T cells with IL-1β, IL-23, anti-CD3, and anti-CD28 mAb, both IL-17A and IL-17F-expressing cells were d ...[more]