Presence, function, and regulation of IL-17F-expressing human CD4⁺ T cells.

ABSTRACT: The pro-inflammatory cytokine IL-17A has been implicated in the immunopathology of inflammatory arthritis. IL-17F bears 50% homology to IL-17A and has recently been suggested to play a role in inflammation. We investigated the induction and cytokine profile of IL-17F⁺ CD4⁺ T cells, and how IL-17F may contribute to inflammation. Upon culture of healthy donor CD4⁺ T cells with IL-1β, IL-23, anti-CD3, and anti-CD28 mAb, both IL-17A and IL-17F-expressing cells were detected. In comparison to IL-17A⁺ IL-17F^- CD4⁺ T cells, IL-17F⁺ IL-17A^- and IL-17A⁺ IL-17F⁺ CD4⁺ T cells contained lower proportions of IL-10-expressing and GM-CSF-expressing cells and higher proportions of IFN-γ

SUBMITTER: Burns LA 

PROVIDER: S-EPMC7187427 | biostudies-literature | 2020 Apr

REPOSITORIES: biostudies-literature