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Tumor ablation using low-intensity ultrasound and sound excitable drug.

ABSTRACT: The cell membrane is a semi-fluid container that defines the boundary of cells, and provides an enclosed environment for vital biological processes. A sound excitable drug (SED) that is non-cytotoxic to cells is developed to disrupt the plasma membrane under gentle ultrasound insonation, 1MHz, 1W/cm2. The frequency and power density of insonation are within the physical therapy and medical imaging windows; thus the applied ultrasound is safe and not harmful to tissues. The insertion of SEDs into the plasma membrane is not toxic to cells; however, the intruding SEDs weaken the membrane's integrity. Under insonation, the ultrasound energy destabilized the SED disrupted membranes, resulting in membrane rupture and eventual cell death. In a xenograft breast tumor model, the SED alone or the ultrasound alone caused little adverse effects to tumor tissue, while the combined treatment triggered necrosis with a brief local insonation of 3min. The described sono-membrane rupture therapy could be a safe alternative to the currently used high-energy tissue ablation technology, which uses X-rays, gamma rays, electron beams, protons, or high-intensity focused ultrasound.

SUBMITTER: Tung CH

PROVIDER: S-EPMC5515481 | biostudies-literature | 2017 Jul

REPOSITORIES: biostudies-literature

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Tumor ablation using low-intensity ultrasound and sound excitable drug.

Tung Ching-Hsuan CH Han Myung Shin MS Kim Young Y Qi Jianjun J O'Neill Brian E BE

Journal of controlled release : official journal of the Controlled Release Society 20170510

The cell membrane is a semi-fluid container that defines the boundary of cells, and provides an enclosed environment for vital biological processes. A sound excitable drug (SED) that is non-cytotoxic to cells is developed to disrupt the plasma membrane under gentle ultrasound insonation, 1MHz, 1W/cm<sup>2</sup>. The frequency and power density of insonation are within the physical therapy and medical imaging windows; thus the applied ultrasound is safe and not harmful to tissues. The insertion o ...[more]

PMID: 28499816

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Dataset Information

Tumor ablation using low-intensity ultrasound and sound excitable drug.

Publications

Tumor ablation using low-intensity ultrasound and sound excitable drug.

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