Ontology highlight
ABSTRACT:
SUBMITTER: D'Souza WN
PROVIDER: S-EPMC5519041 | biostudies-literature | 2017
REPOSITORIES: biostudies-literature
D'Souza Warren N WN Douangpanya Jason J Mu Sharon S Jaeckel Peter P Zhang Ming M Maxwell Joseph R JR Rottman James B JB Labitzke Katja K Willee Angela A Beckmann Holger H Wang Yingcai Y Li Yang Y Schwandner Ralf R Johnston James A JA Towne Jennifer E JE Hsu Hailing H
PloS one 20170720 7
Inflammatory bowel disease (IBD) is associated with a loss of intestinal barrier function and dysregulated immune responses. It has been shown that short chain fatty acids (SCFAs) are protective in IBD and that GPR43 mediates the protective effects of SCFAs. In this study, we investigated the effects of SCFAs in comparison to highly specific GPR43 agonists on human intestinal epithelial and immune cells. Our results confirm that SCFAs are enhancers of barrier function in intestinal epithelial ce ...[more]