Ontology highlight
ABSTRACT:
SUBMITTER: Boeske A
PROVIDER: S-EPMC5519724 | biostudies-literature | 2017 Jul
REPOSITORIES: biostudies-literature
Boeske Alexandra A Schwarten Melanie M Ma Peixiang P Tusche Markus M Mötter Jessica J Möller Christina C Neudecker Philipp P Hoffmann Silke S Willbold Dieter D
Scientific reports 20170720 1
HIV-1 Nef is an important pathogenic factor for HIV/AIDS pathogenesis. Studies have shown that the association of Nef with the inner leaflet of the plasma membrane and with endocytic and perinuclear vesicles is essential for most activities of Nef. Using purified recombinant proteins in pull-down assays and by co-immunoprecipitation assays we demonstrate that Nef binds directly and specifically to all GABARAP family members, but not to LC3 family members. Based on nuclear magnetic resonance (NMR ...[more]