Ontology highlight
ABSTRACT:
SUBMITTER: Buffalo CZ
PROVIDER: S-EPMC6880166 | biostudies-literature | 2019 Dec
REPOSITORIES: biostudies-literature
Buffalo Cosmo Z CZ Iwamoto Yuichiro Y Hurley James H JH Ren Xuefeng X
Journal of virology 20191126 24
The accessory protein Nef of human immunodeficiency virus (HIV) is a primary determinant of viral pathogenesis. Nef is abundantly expressed during infection and reroutes a variety of cell surface proteins to disrupt host immunity and promote the viral replication cycle. Nef counteracts host defenses by sequestering and/or degrading its targets via the endocytic and secretory pathways. Nef does this by physically engaging a number of host trafficking proteins. Substantial progress has been achiev ...[more]