Unknown

Dataset Information

0

Log D versus HPLC derived hydrophobicity: The development of predictive tools to aid in the rational design of bioactive peptoids.


ABSTRACT: Hydrophobicity has proven to be an extremely useful parameter in small molecule drug discovery programmes given that it can be used as a predictive tool to enable rational design. For larger molecules, including peptoids, where folding is possible, the situation is more complicated and the average hydrophobicity (as determined by RP-HPLC retention time) may not always provide an effective predictive tool for rational design. Herein, we report the first ever application of partitioning experiments to determine the log D values for a series of peptoids. By comparing log D and average hydrophobicities we highlight the potential advantage of employing the former as a predictive tool in the rational design of biologically active peptoids.

SUBMITTER: Bolt HL 

PROVIDER: S-EPMC5519928 | biostudies-literature |

REPOSITORIES: biostudies-literature

Similar Datasets

| S-EPMC4862414 | biostudies-literature
| S-EPMC6264295 | biostudies-literature
| S-EPMC6100324 | biostudies-other
| S-EPMC8615513 | biostudies-literature
| S-EPMC11375592 | biostudies-literature
| S-EPMC3646530 | biostudies-literature
| S-EPMC5573320 | biostudies-literature
2009-12-22 | GSE14974 | GEO
| S-EPMC6154496 | biostudies-literature
| S-EPMC1174920 | biostudies-literature