Ontology highlight
ABSTRACT:
SUBMITTER: Moreno E
PROVIDER: S-EPMC6264295 | biostudies-literature | 2011 Sep
REPOSITORIES: biostudies-literature
Molecules (Basel, Switzerland) 20110913 9
As reported in our previous papers, a series of quinoxaline-2-carboxamide 1,4-di-N-oxide derivatives were synthesized and studied as anti-tuberculosis agents. Here, the capability of the shake-flask method was studied and the retention time (expressed as log K) of 20 compounds were determined by RP-HPLC analysis. We found that the prediction of log P by the RP-HPLC analysis can result in a high accuracy and can replace the shake-flask method avoiding the experimental problems presented by quinox ...[more]