Ontology highlight
ABSTRACT:
SUBMITTER: Yue M
PROVIDER: S-EPMC5521851 | biostudies-literature | 2017 Jul
REPOSITORIES: biostudies-literature
Yue Minghui M Ogawa Akiyo A Yamada Norishige N Charles Richard John Lalith JL Barski Artem A Ogawa Yuya Y
PLoS genetics 20170707 7
Long non-coding RNA Xist plays a crucial role in establishing and maintaining X-chromosome inactivation (XCI) which is a paradigm of long non-coding RNA-mediated gene regulation. Xist has Xist-specific repeat elements A-F which are conserved among eutherian mammals, underscoring their functional importance. Here we report that Xist RNA repeat E, a conserved Xist repeat element in the Xist exon 7, interacts with ASH2L and contributes to maintenance of escape gene expression level on the inactive ...[more]