Ontology highlight
ABSTRACT:
SUBMITTER: Pichugin A
PROVIDER: S-EPMC5522243 | biostudies-literature | 2017 Jun
REPOSITORIES: biostudies-literature
Pichugin Andrey A Iarovaia Olga V OV Gavrilov Alexey A Sklyar Ilya I Barinova Natalja N Barinov Aleksandr A Ivashkin Evgeny E Caron Gersende G Aoufouchi Said S Razin Sergey V SV Fest Thierry T Lipinski Marc M Vassetzky Yegor S YS
Oncotarget 20170601 25
The immunoglobulin heavy chain (IGH) gene loci are subject to specific recombination events during B-cell differentiation including somatic hypermutation and class switch recombination which mark the end of immunoglobulin gene maturation in germinal centers of secondary lymph nodes. These two events rely on the activity of activation-induced cytidine deaminase (AID) which requires DNA double strand breaks be created, a potential danger to the cell. Applying 3D-fluorescence in situ hybridization ...[more]