Ontology highlight
ABSTRACT:
SUBMITTER: Sledzinska A
PROVIDER: S-EPMC5528732 | biostudies-literature | 2015 Dec
REPOSITORIES: biostudies-literature
Śledzińska Anna A Menger Laurie L Bergerhoff Katharina K Peggs Karl S KS Quezada Sergio A SA
Molecular oncology 20151026 10
The term 'inhibitory checkpoint' refers to the broad spectrum of co-receptors expressed by T cells that negatively regulate T cell activation thus playing a crucial role in maintaining peripheral self-tolerance. Co-inhibitory receptor ligands are highly expressed by a variety of malignancies allowing evasion of anti-tumour immunity. Recent studies demonstrate that manipulation of these co-inhibitory pathways can remove the immunological brakes that impede endogenous immune responses against tumo ...[more]