Ontology highlight
ABSTRACT:
SUBMITTER: Sebastiani P
PROVIDER: S-EPMC5533653 | biostudies-literature | 2017 Jul
REPOSITORIES: biostudies-literature
Sebastiani Paola P Bae Harold H Gurinovich Anastasia A Soerensen Mette M Puca Annibale A Perls Thomas T TT
Mechanisms of ageing and development 20170128 Pt B
Searching for genetic determinants of human longevity has been challenged by the rarity of data sets with large numbers of individuals who have reached extreme old age, inconsistent definitions of the phenotype, and the difficulty of defining appropriate controls. Meta-analysis - a statistical method to summarize results from different studies - has become a common tool in genetic epidemiology to accrue large sample sizes for powerful genetic association studies. In conducting a meta-analysis of ...[more]