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Ligand-Enabled Pd(II)-Catalyzed C(sp³)-H Lactonization Using Molecular Oxygen as Oxidant.

ABSTRACT: Pd(II)-catalyzed C-H lactonization of o-methyl benzoic acid substrates has been achieved using molecular oxygen as the oxidant. This finding provides a rare example of C-H oxygenation through Pd(II)/Pd(0) catalysis as well as a method to construct biologically important benzolactone scaffolds. The use of a gas mixture of 5% oxygen in nitrogen demonstrated the possibility for its application in pharmaceutical manufacturing.

SUBMITTER: Qian S

PROVIDER: S-EPMC8023385 | biostudies-literature | 2020 May

REPOSITORIES: biostudies-literature

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Ligand-Enabled Pd(II)-Catalyzed C(sp3)-H Lactonization Using Molecular Oxygen as Oxidant.

Qian Shaoqun S Li Zi-Qi ZQ Li Minyan M Wisniewski Steven R SR Qiao Jennifer X JX Richter Jeremy M JM Ewing William R WR Eastgate Martin D MD Chen Jason S JS Yu Jin-Quan JQ

Organic letters 20200424 10

Pd(II)-catalyzed C-H lactonization of o-methyl benzoic acid substrates has been achieved using molecular oxygen as the oxidant. This finding provides a rare example of C-H oxygenation through Pd(II)/Pd(0) catalysis as well as a method to construct biologically important benzolactone scaffolds. The use of a gas mixture of 5% oxygen in nitrogen demonstrated the possibility for its application in pharmaceutical manufacturing. ...[more]

PMID: 32330054

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