Ontology highlight
ABSTRACT:
SUBMITTER: Liu Y
PROVIDER: S-EPMC5535819 | biostudies-literature | 2017 Jun
REPOSITORIES: biostudies-literature
Liu Yuhang Y Pan Junhua J Jenni Simon S Raymond Donald D DD Caradonna Tim T Do Khoi T KT Schmidt Aaron G AG Harrison Stephen C SC Grigorieff Nikolaus N
Journal of molecular biology 20170512 12
Structure-based vaccine design depends on extensive structural analyses of antigen-antibody complexes.Single-particle electron cryomicroscopy (cryoEM) can circumvent some of the problems of x-ray crystallography as a pipeline for obtaining the required structures. We have examined the potential of single-particle cryoEM for determining the structure of influenza-virus hemagglutinin (HA):single-chain variable-domain fragment complexes, by studying a complex we failed to crystallize in pursuing an ...[more]